| Description | Lucigenin (NSC-151912) (L-6868) is a chemiluminescent probe used to indicate the presence of endogenously generated superoxide anion radicals in cells. |
| In vitro | 当Lucigenin通过一个自由基种类进行单电子还原后，其后形态的Lucigenin展现出可测量的放大化学发光，可与系统中存在的相应反应性自由基种类的数量相关联。除了指示细胞中自由基的存在外，Lucigenin还显示与氧化还原活性的氧化还原酶发生相互作用。研究表明，Lucigenin介导黄嘌呤氧化酶还原细胞色素C并增加NADPH氧化速率。 |
| Synonyms | NSC-151912, L-6868, 光泽精 |
| molecular weight | 510.5 |
| Molecular formula | C28H22N4O6 |
| CAS | 2315-97-1 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (156.71 mM) |
| References | 1. Li Y, et al. Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J Biol Chem. 1998 Jan 23;273(4):2015-23. 2. Rost M, et al. What do we measure with luminol-, lucigenin- and penicillin-amplified chemiluminescence? 1. Investigations with hydrogen peroxide and sodium hypochlorite. J Biolumin Chemilumin. 1998 Nov-Dec;13(6):355-63. |