| Description | LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC 50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders [1]. |
| In vitro | LTA4H-IN-1 (15 min) inhibits the LTA4H-catalyzed hydrolysis of 7-amino-4-methylcoumarin (AMC) derivative of Arginine (Arg-AMC) with an IC 50 of 2 nM [1]. LTA4H-IN-1 (30 min) inhibits LTB4 biosynthesis in a human whole blood assay (hWB), with an IC 50 of 167 nM [1]. |
| In vivo | LTA4H-IN-1 (0.3 mg/kg; a single p.o.) inhibits the -43% release of LTB4 compared to vehicle control in mice [1]. |
| Synonyms | LYS-006 |
| molecular weight | 392.77 |
| Molecular formula | C16H14ClFN6O3 |
| CAS | 1799681-85-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |