| Description | Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2. |
| In vitro | Lp-PLA2-IN-2 inhibits Human Lp-PLA2 with an IC50 of 62 nM in PED6 assay. |
| In vivo | Lp-PLA2-IN-2 (1 mg/kg;?i.v.) treament in rats shows that the Cl, Vss and t1/2 values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively[1]. |
| Target activity | Lp-PLA2:120 nM |
| molecular weight | 394.46 |
| Molecular formula | C19H23FN2O4S |
| CAS | 2071636-15-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Woolford AJ, et al. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J Med Chem. 2016 Dec 8;59(23):10738-10749. |