| Description | Lotrifen (Privaprol), an agent of non-hormonal antifertility, causes the arrest and involution of pregnancy. It acts, after the implantation of the blastocyst, directly on the product of conception, which undergoes a slow and gradual degenerative process and ends with the reabsorption or expulsion of it. |
| Synonyms | Privaprol, L-12717, DL 717-IT, L 12717, L12717, Canocenta |
| molecular weight | 279.72 |
| Molecular formula | C16H10ClN3 |
| CAS | 66535-86-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Wanke R, Hermanns W. Adverse effects of the antifertility agent DL 717-IT (Canocenta, Byk Gulden, FRG). Pathological findings in the rabbit. Res Commun Chem Pathol Pharmacol. 1989 Jan;63(1):69-80. 2. Lerner LJ. Development of novel embryotoxic compounds for interceptive fertility control in the dog. J Reprod Fertil Suppl. 1989;39:251-65. 3. Kälin S, et al. [Sterile, purulent meningitis and generalized vasculitis caused by a new drug for prevention of nidation in the dog]. Schweiz Arch Tierheilkd. 1987 Jul;129(7):335-42. German. |