| Description | LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 shows antibacterial activity with a MIC of 2 μg/ml against E. coli MG1655 [1]. |
| In vitro | The P. aeruginosa ΔlolCDE::CTX-lolCDE E. coli strain becomes more susceptible to LolCDE-IN-2 (compound 2A) when either the MexAB-OprM efflux pump is lacking or the permeability of its OM is increased by the expression of the FpvA-ΔP protein; in each case, these strains show an MIC of 16 μg/ml [1]. The LolCDE-IN-2 likely makes contact with residues that are found in the binding regions in E. coli LolCDE. |
| molecular weight | 367.4 |
| Molecular formula | C22H17N5O |
| CAS | 2748443-01-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Christian Lorenz, et al. Correct Sorting of Lipoproteins into the Inner and Outer Membranes of Pseudomonas aeruginosa by the Escherichia coli LolCDE Transport System. Molecular Biology and Physiology. |