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Lobucavir

CAS No.: 126062-18-8

Lobucavir inhibits the replication of the HIV virus in T cells, monocytesmacrophages in vitro by inhibiting DNA polymera
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Description Lobucavir inhibits the replication of the HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis.
Synonyms BMS180194, BMS 180194, SQ 34,514, SQ-34514, SQ 34514, SQ34514
molecular weight 265.27
Molecular formula C11H15N5O3
CAS 126062-18-8
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility DMSO: Soluble
References 1. Woicke J, Durham SK, Mense MG. Lobucavir-induced proliferative changes in mice. Exp Toxicol Pathol. 2007 Nov;59(3-4):197-204. Epub 2007 Oct 17. PubMed PMID: 17942294. 2. Yang Z, Manitpisitkul P, Sawchuk RJ. In situ studies of regional absorption of lobucavir and ganciclovir from rabbit intestine and predictions of dose-limited absorption and associated variability in humans. J Pharm Sci. 2006 Oct;95(10):2276-92. PubMed PMID: 16883564. 3. Genovesi EV, Lamb L, Medina I, Taylor D, Seifer M, Innaimo S, Colonno RJ, Clark JM. Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection. Antiviral Res. 2000 Dec;48(3):197-203. PubMed PMID: 11164506. 4. Hanson RL, Shi Z, Brzozowski DB, Banerjee A, Kissick TP, Singh J, Pullockaran AJ, North JT, Fan J, Howell J, Durand SC, Montana MA, Kronenthal DR, Mueller RH, Patel RN. Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug. Bioorg Med Chem. 2000 Dec;8(12):2681-7. PubMed PMID: 11131158.