| Description | LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases. |
| Synonyms | LK-157, LK157 |
| molecular weight | 263.29 |
| Molecular formula | C14H17NO4 |
| CAS | 209536-74-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Paukner S, Hesse L, Prezelj A, Solmajer T, Urleb U. In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor. Antimicrob Agents Chemother. 2009 Feb;53(2):505-11. doi: 10.1128/AAC.00085-08. Epub 2008 Dec 15. PubMed PMID: 19075067; PubMed Central PMCID: PMC2630636. 2. Iglicar P, Legen I, Vilfan G, Selic L, Prezelj A. Permeability of a novel beta-lactamase inhibitor LK-157 and its ester prodrugs across rat jejunum in vitro. J Pharm Pharmacol. 2009 Sep;61(9):1211-8. doi: 10.1211/jpp/61.09.0011. PubMed PMID: 19703371. 3. Swathi CH, Chikala R, Ratnakar KS, Sritharan V. A structural, epidemiological & genetic overview of Klebsiella pneumoniae carbapenemases (KPCs). Indian J Med Res. 2016 Jul;144(1):21-31. doi: 10.4103/0971-5916.193279. Review. PubMed PMID: 27834322; PubMed Central PMCID: PMC5116894. 4. Fernea A, Galleni M, Frère JM. Kinetics of the Interaction between BAL29880 and LK157 and the Class C β-Lactamase CHE-1. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1747-50. doi: 10.1128/AAC.02062-15. PubMed PMID: 26729500; PubMed Central PMCID: PMC4775998. |