| Description | Liproxstatin-1 hydrochloride is a high-potency ferroptosis inhibitor capable of effectively preventing ferroptotic cell death, with an IC50 value of 22 nM [1]. |
| In vitro | Liproxstatin-1 shows antiferroptotic activity with an IC 50 of approximately 38 nM in mouse embryonic fibroblasts [2]. |
| In vivo | Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4 -/- kidney and in an ischaemia/reperfusion-induced tissue injury model [1]. |
| molecular weight | 377.31 |
| Molecular formula | C19H22Cl2N4 |
| CAS | 2250025-95-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |