| Description | Lipoxin A4 (LXA4) is a lipoxygenase-derived arachidonate-like mediator with anti-inflammatory properties.Lipoxin A4 attenuates MSU crystal-induced NLRP3 inflammasome activation through inhibition of Nrf2, and regulates M1/M2 macrophage polarization through the FPR2-IRF pathway.Lipoxin inhibits oxidative stress and inflammation. |
| In vitro | Lipoxin A4 (LXA4；NHEKs) 抑制 IL-6 和 IL-8 的表达，下调细胞周期蛋白 D1 的表达，并抑制 NHEKs 中的 ERK1/2 磷酸化和 NF-kB-p65 核易位。[2]Lipoxin A4 (100 nM；预孵育 30 分钟；NHEKs) 抑制 NHEKs 增殖，无论有无 LPS (10 μg/mL) 刺激。[2]Lipoxin A4 (100 nM；预孵育 30 分钟) 下调 LPS 诱导的角质形成细胞中 HMGB1 的分泌和表达。[1] |
| Synonyms | LXA4 |
| molecular weight | 352.47 |
| Molecular formula | C20H32O5 |
| CAS | 89663-86-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | PBS (pH 7.2): 0.05 mg/mL H2O: < 1mg/mL (insoluble or slightly soluble.) Ethanol: 30 mg/mL (85.11 mM), Sonication is recommended. |
| References | 1. Hu F, et al. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes associated with the ERK1/2 and NF-κB pathways. J Dermatol Sci. 2015 Jun;78(3):181-8. 2. Bozinovski S, et al. Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):935-40. 3. Liu X, et al. Lipoxin A4 and its analog suppress inflammation by modulating HMGB1 translocation and expression in psoriasis. Sci Rep. 2017 Aug 2;7(1):7100. 4. Dong W, et al. Expression of lipoxin A4, TNFα and IL-1β in maternal peripheral blood, umbilical cord blood and placenta, and their significance in pre-eclampsia. Hypertens Pregnancy. 2014 Nov;33(4):449-56. 5. Shimizu S, et al. Pro-resolution mediator lipoxin A4 and its receptor in upper airway inflammation. Ann Otol Rhinol Laryngol. 2013 Nov;122(11):683-9. |