| Description | Linoleoyl glycine, a modified polyunsaturated fatty acid, is an endogenous homologue of linoleoyl glycine. Linoleoyl glycine activates human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in xenopus oocytes from mammalian skin, spinal cord and brain, and has shown analgesic activity in animal studies. |
| In vivo | Llinoleoyl glycine [Lin-GLY] shortens ADP and QT interval in guinea pig heart.[1] |
| Target activity | AEA:25 µM |
| molecular weight | 337.5 |
| Molecular formula | C20H35NO3 |
| CAS | 2764-03-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 112.5 mg/mL (333.3 mM), Sonication is recommended. |
| References | 1. Skarsfeldt MA, et al. Polyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivo. Acta Physiol (Oxf). 2020;229(4):e13471. |