| Description | LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. |
| In vitro | LIN28 inhibitor LI71 直接结合冷冻休克域(CSD)，抑制白血病细胞和胚胎干细胞中LIN28对let-7的活性。 |
| Target activity | LIN28:7 uM (IC50) |
| molecular weight | 335.4 |
| Molecular formula | C21H21NO3 |
| CAS | 1357248-83-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 27.5 mg/mL (81.99 mM) |
| References | 1. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101. |