| Description | Liga 20 is a semisynthetic GM1 ganglioside with N-dichloroacetylsphingosine that protecting neurons in culture against glutamate toxicity. |
| Synonyms | Liga-20, Liga20 |
| molecular weight | 1391.29 |
| Molecular formula | C57H97Cl2N3O31 |
| CAS | 126586-85-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Schneider JS, DiStefano L. LIGA 20 increases striatal dopamine levels in aged MPTP-treated mice refractory to GM1 ganglioside treatment. Neuroreport. 1993 Nov 18;5(2):103-4. PubMed PMID: 8110995. 2. Wu G, Lu ZH, Wang J, Wang Y, Xie X, Meyenhofer MF, Ledeen RW. Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci. 2005 Nov 23;25(47):11014-22. PubMed PMID: 16306414. 3. Wu G, Lu ZH, Xie X, Li L, Ledeen RW. Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20. J Neurochem. 2001 Feb;76(3):690-702. PubMed PMID: 11158239. 4. Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, Lu ZH, Forsayeth J, Ledeen RW. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol. 2015 Jan;263:177-89. doi: 10.1016/j.expneurol.2014.10.010. Epub 2014 Oct 23. PubMed PMID: 25448159. |