LH-RH, salmon acetate(86073-88-3 free base) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	LH-RH, salmon acetate(86073-88-3 free base) (Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate) is a pituitary Hormone synthesized in the hypothalamus and plays a crucial role in the control of reproductive function.
In vitro	促性腺激素释放激素（LHRH）是控制生殖功能的关键激素，通过激活Gi-cAMP细胞内信号通路发挥抗增殖作用。LHRH可能在黑色素瘤细胞的细胞增殖和转移行为上起抑制作用[1]。作为调控生殖的中枢，LHRH通过刺激垂体释放促黄体生成激素（LH）和促卵泡激素（FSH），进而促进性腺功能并调节性激素分泌。LHRH的效应通过存在于垂体性腺细胞上的高亲和力G蛋白偶联LHRH受体（LHRH-R）介导。对LHRH的反应在不同条件下有所变化，且严重依赖于给予性腺细胞的给药方式和剂量[2]。
Synonyms	Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate
molecular weight	1272.35
Molecular formula	C62H77N15O15
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 10 mM
References	1. Moretti RM, et al. Inhibitory activity of luteinizing hormone-releasing hormone on tumor growth and progression. Endocr Relat Cancer. 2003 Jun;10(2):161-7.

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