| Description | Levomenol ((-)-α-BISABOLOL) is a sesquiterpene alcohol that has been found in the essential oils of several aromatic plants, with exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. |
| In vitro | Levomenol能够在该寄生虫的鞭毛体阶段激活程序性细胞死亡过程。它引起磷脂酰丝氨酸的外化和膜损伤。此外，该化合物还能降低线粒体膜电位和总ATP水平。这些结果突显了Levomenol对抗L. amazonensis和L. infantum的潜力，进一步的研究应当进行以确立其作为新型利什曼病治疗剂的地位[1]。 |
| In vivo | Levomenol 抑制 L. amazonensis 提示体和非利什曼体的生长（IC50s分别为8.07和4.29 μg/ml）。它也减少了 L. infantum 和 L. donovani 非利什曼体的生长（IC50s 分别为56.9和39.4 μM），同时具有大于1,000 μM 的细胞毒性浓度（CC50）值在L929细胞中[2]。 |
| Synonyms | 没药醇, (-)-α-BISABOLOL, (-)-α-红没药醇 |
| molecular weight | 222.37 |
| Molecular formula | C15H26O |
| CAS | 23089-26-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 22.5 mg/mL (101.18 mM) |
| References | 1. Soumaya H , Ines S , López-Arencibia Atteneri, et al. Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil[J]. Parasitology Research, 2018. 2. Corpas-López, Victoriano, Morillas-Márquez, Francisco, Navarro-Moll, M. Concepción, et al. (?)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis[J]. Journal of Natural Products, 2015, 78(6):1202-1207. |