| Description | Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen. |
| Synonyms | L-Leucinal |
| molecular weight | 115.17 |
| Molecular formula | C6H13NO |
| CAS | 82473-52-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Davis KR, Hernandez DE, Wolfenden R. Leucinal inhibits brain aminopeptidase activity and potentiates analgesia induced by leu-enkephalen. Pharmacol Biochem Behav. 1983 Nov;19(5):791-4. PubMed PMID: 6647514. 2. Sträter N, Lipscomb WN. Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography. Biochemistry. 1995 Nov 14;34(45):14792-800. PubMed PMID: 7578088. 3. Princiotta MF, Schubert U, Chen W, Bennink JR, Myung J, Crews CM, Yewdell JW. Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):513-8. Epub 2001 Jan 9. PubMed PMID: 11149939; PubMed Central PMCID: PMC14618. 4. Ito H, Watanabe M, Kim YT, Takahashi K. Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues. J Enzyme Inhib Med Chem. 2009 Feb;24(1):279-86. doi: 10.1080/14756360802166921 . PubMed PMID: 18830882. |