Description | [Leu31,Pro34]-Neuropeptide Y (porcine), is a selective and high affinity agonist of neuropeptide Y (NPY) Y1 receptor with anxiolytic effects. |
In vitro | 在一系列人类神经母细胞瘤细胞系及大鼠PC-12细胞上,[Leu31,Pro34]-Neuropeptide Y (porcine) 从表达Y1受体的细胞中置换了放射性标记的NPY[1]。 |
Synonyms | LEU 31, PRO34]-神经肽Y(猪) |
molecular weight | 4223 |
Molecular formula | C190H286N54O56 |
CAS | 125580-28-1 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility | 0.25% acetic acid: 1 mg/ml H2O: 90 mg/mL (21.31 mM) |
References | 1. Kokare DM, et, al. Interaction between neuropeptide Y and alpha-melanocyte stimulating hormone in amygdala regulates anxiety in rats. Brain Res. 2005 May 10;1043(1-2):107-14. 2. Fuhlendorff J, et, al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. |
Citations | 1. Lv X, Gao F, Li T P, et al. Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY. Elife. 2021, 10: e70324. |