| Description | Letosteine (Viscotiol) is an orally active, effective, and safe expectorant that can be used in the study of acute or chronic respiratory diseases, for example, bronchopulmonary disease. Letosteine dissolves bronchial mucus and reduces symptoms of respiratory inflammation and restores gas exchanges and natural defense mechanisms in the lung[1] [2] [3]. |
| In vivo | Letosteine在施予Sprague-Dawley大鼠（20 mg/kg，静脉注射或口服，一次）后，Letosteine 快速地通过尿液排泄[1]。 |
| Synonyms | Viscotiol |
| molecular weight | 279.38 |
| Molecular formula | C10H17NO4S2 |
| CAS | 53943-88-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (196.86 mM) |
| References | 1. Jia L. Letosteine. John Wiley & Sons, Ltd, 2014. 2. Macquet V, et al. A new contribution to the treatment of chronic bronchopneumopathies: letosteine. Lille Med. 1979;24(9):735-738. 3. Zhou Y, et al. Efficacy and safety of letosteine in the treatment of sputum thickening and expectoration difficulty in patients with respiratory diseases: a multicenter, randomized, double-masked, double dummy, positive drug parallel controlled trial. Pharmazie. 2014 Nov;69(11):842-9. 4. Gachon F, et al. Disposition and metabolism of letosteine in rats. Drug Metab Dispos. 1988;16(6):853-857. |