| Description | LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT). |
| In vitro | LEI110在PLA2G16过度表达的U2OS细胞中降低花生四烯酸水平，并减轻人类HepG2细胞中油酸诱导的脂肪变性[1]。 |
| Target activity | PLA2G16:20 nM(Ki) |
| molecular weight | 456.46 |
| Molecular formula | C25H23F3N2O3 |
| CAS | 2313525-90-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (109.54 mM) |
| References | 1. Zhou J, et al. Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI. ACS Chem Biol. 2019 Feb 15;14(2):164-169. |