| Description | LCL521 dihydrochloride is a compound that functions as an inhibitor of both acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase). |
| In vitro | LCL521 (10μM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1]. |
| Synonyms | 1,3DMG-B13 dihydrochloride |
| molecular weight | 665.69 |
| Molecular formula | C31H54Cl2N4O7 |
| CAS | 1226759-47-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 20.83 mg/mL (31.29 mM), Sonication is recommended. |
| References | 1. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. |