PeptideDB

LB80317

CAS No.: 441785-24-6

LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.
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Description LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.
Target activity DNA synthesis of HBV:0.5 μM (EC50)
Synonyms LB-80317, ANA 317, ANA317, LB 80317, ANA-317
molecular weight 315.22
Molecular formula C10H14N5O5P
CAS 441785-24-6
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Jung JA, Kim SR, Kim TE, Kim JR, Lee SY, Huh W, Ko JW. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64. PubMed PMID: 22981147. 2. Yuen MF, Lee SH, Kang HM, Kim CR, Kim J, Ngai V, Lai CL. Pharmacokinetics of LB80331 and LB80317 following oral administration of LB80380, a new antiviral agent for chronic hepatitis B (CHB), in healthy adult subjects, CHB patients, and mice. Antimicrob Agents Chemother. 2009 May;53(5):1779-85. doi: 10.1128/AAC.01290-08. Epub 2009 Feb 17. PubMed PMID: 19223649; PubMed Central PMCID: PMC2681521. 3. Yuen MF, Kim J, Kim CR, Ngai V, Yuen JC, Min C, Kang HM, Shin BS, Yoo SD, Lai CL. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83. PubMed PMID: 17302367.