| Description | LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1]. |
| In vivo | LB244 (10 mg/kg, po; 5 mg/kg, ip) 在小鼠药代动力学研究中表现出有限的口服生物利用度（Cmax=0.04 μM），并具有较短半衰期（T1/2=2.8 h）。LB244 的体内清除率为2854.3 mL/min/kg [1]。 |
| molecular weight | 537.57 |
| Molecular formula | C30H27N5O5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |