| Description | Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75). |
| Target activity | HIV-1 integrase-LEDGF/p75:94.07 μM (IC50), GLUT1:15 μM (Ki) |
| Synonyms | 薰草菌素B |
| molecular weight | 365.38 |
| Molecular formula | C21H19NO5 |
| CAS | 125697-91-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/mL (177.89 mM) |
| References | 1. Agharbaoui FE, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-83 2. Alioua A,et al. Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14560-5 3. Fujii E, et al. Role of nitric oxide, prostaglandins and tyrosine kinase in vascular endothelial growth factor-induced increase in vascular permeability in mouse skin. Naunyn Schmiedebergs Arch Pharmacol. 1997 Oct;356(4):475-80 |