| Description | Laninamivir (R 125489) is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively). |
| In vitro | Laninamivir对p57N2、p09N1和N5展现出与Zanamivir相似的结合模式，有效抑制了包括普遍存在的His274Tyr置换在内的常见奥司他韦耐药病毒[1]。 |
| Target activity | N5:0.90 nM (IC50), p09N1:1.83 nM (IC50), p57N2:3.12 nM (IC50) |
| Synonyms | (4S,5R,6R)-5-乙酰氨基-4-胍基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-甲酸, R 125489 |
| molecular weight | 346.34 |
| Molecular formula | C13H22N4O7 |
| CAS | 203120-17-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Insoluble H2O: 10 mM |
| References | 1. Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249. |