| Description | Laninamivir octanoate (CS-8958) is a long acting influenza neuraminidase (NA) inhibitor which shows superior anti-influenza virus activity. |
| In vitro | CS-8958对H1N1病毒株、H3N2病毒株及H2N2 (A/Singapore/1/57) 病毒表现出抑制活性，其半抑制浓度（IC50）分别为631-1170 nM、39.2-221 nM和128 nM[1]。 |
| In vivo | CS-8958(95 μg/kg；经鼻给药；三剂量；在感染前4小时、感染后4小时和17小时给药)治疗在感染模型中显示出显著的延长生命效果[1]。 |
| Synonyms | 辛酸拉尼米韦, CS-8958 |
| molecular weight | 472.53 |
| Molecular formula | C21H36N4O8 |
| CAS | 203120-46-1 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (211.63 mM), Sonication is recommended. |
| References | 1. Yamashita M . CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity[J]. Antimicrobial Agents & Chemotherapy, 2009, 53. 2. Hideyuki Ikematsu, et al. Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza. Expert Rev Anti Infect Ther. 2011 Oct;9(10):851-7. |