| Description | L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. |
| In vivo | In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism. |
| Synonyms | L-Thyroxine-13C9,15N |
| molecular weight | 786.8 |
| Molecular formula | C15H11I4NO4 |
| CAS | 1431868-11-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 0.14 mg/mL DMSO:PBS (pH 7.2) (1:1): 0.50 mg/mL DMSO: 2.5 mg/mL |