| Description | L-Propargylglycine ((S)-Propargylglycine) is an inhibitor of the enzyme. |
| In vitro | l-propargylglycine (LPG) 以剂量依赖和时间依赖的方式不可逆地抑制了来自Crotalus adamanteus和Crotalus atrox的酶。不可逆性失活得到了底物l-phenylalanine的显著保护。Kitz-Wilson重绘的抑制动力学揭示了可逆酶-LPG复合体的形成，这发生在酶的修饰和失活之前。UV-visible和荧光光谱强烈表明LPG与酶活性位点残基之间形成了共价加合物。分子建模研究揭示了FAD结合位点、底物结合位点和螺旋域在SV-LAAO中是保守的，且His223和Arg322是重要的活性位点残基，很可能被LPG修饰。 |
| Synonyms | (S)-Propargylglycine, (S)-alpha.Propargylglycine, Propargylglycine, L-炔丙基甘氨酸 |
| molecular weight | 113.11 |
| Molecular formula | C5H7NO2 |
| CAS | 23235-01-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: Slightly soluble |
| References | 1. Irreversible inactivation of snake venom l-amino acid oxidase by covalent modification during catalysis of l-propargylglycine |