| Description | L-Methionine γ-lyase (Methionine lyase), a multifaceted enzyme in the γ-family of pyridoxal-5’-phosphate (PLP)-dependent enzymes, catalyzes the α, γ-elimination of L-methionine and homocysteine. This enzyme exhibits anticancer and anti-infectious properties and is utilized in homocysteinemia research [1] [2] [3]. |
| In vitro | L-Methionine γ-lyase（蛋氨酸裂解酶）在高达1000 μg/mL浓度和24小时处理下，对肝癌细胞系（Hep-G2 和 HCT-116）展示出明显的抗癌活性[1]。此外，该化合物对多种癌症细胞系，包括结直肠癌、肝细胞癌、卵巢腺癌以及肺腺癌细胞显示出细胞毒性作用，其IC 50 值范围在0.05 - 2.14 Unit/mL之间[2]。 |
| In vivo | L-蛋氨酸γ裂解酶（亦称为蛋氨酸裂解酶）（3 × 10^10 CFU，4天，皮下注射）能够缓解由P. gingivalis在BALB/c小鼠中诱发的牙周病[3]。 |
| Synonyms | Methionine lyase |
| molecular weight | N/A |
| CAS | 42616-25-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |