L-796568 dihydrochloride Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	L-796568, is a β3 adrenergic receptor agonist. L-796568 is a potent full beta(3) agonist (EC(50) = 3.6 nM, 94% activation) with >600-fold selectivity over the human beta(1) and beta(2) receptors, which also displays good oral bioavailability in several mammalian species, as well as an extended duration of action.
Synonyms	L 796568, L-796568, L796568
molecular weight	697.62
Molecular formula	C31H29Cl2F3N4O3S2
CAS	211031-81-1
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Dow RL, Paight ES, Schneider SR, Hadcock JR, Hargrove DM, Martin KA, Maurer TS, Nardone NA, Tess DA, DaSilva-Jardine P. Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonists. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3235-40. PubMed PMID: 15149682. 2. Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Nov;25(9):747-71. PubMed PMID: 14685303. 3. Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, Astrup A. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr. 2002 Oct;76(4):780-8. PubMed PMID: 12324291. 4. van Baak MA, Hul GB, Toubro S, Astrup A, Gottesdiener KM, DeSmet M, Saris WH. Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men. Clin Pharmacol Ther. 2002 Apr;71(4):272-9. PubMed PMID: 11956510.

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