| Description | L 708286 is an agent of peptide-based phenethylcarbamoyldifluoromethylene. It is a slow-binding inhibitor of human leucocyte elastase (HLE). |
| Synonyms | L708286, L-708286, DFKi |
| molecular weight | 508.56 |
| Molecular formula | C25H34F2N4O5 |
| CAS | 119720-81-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Zhang L, Song L, Terracina G, Liu Y, Pramanik B, Parker E. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides. Biochemistry. 2001 Apr 24;40(16):5049-55. PubMed PMID: 11305921. 2. Masek BB, Merchant A, Matthew JB. Molecular skins: a new concept for quantitative shape matching of a protein with its small molecule mimics. Proteins. 1993 Oct;17(2):193-202. PubMed PMID: 8265566. 3. Knight WB, Swiderek KM, Sakuma T, Calaycay J, Shively JE, Lee TD, Covey TR, Shushan B, Green BG, Chabin R, et al. Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex. Biochemistry. 1993 Mar 2;32(8):2031-5. PubMed PMID: 8095408. |