| Description | L 659874 is a cyclic hexapeptide. It is also a tachykinin antagonist. |
| Synonyms | L659874, L-659874 |
| molecular weight | 821.98 |
| Molecular formula | C40H55N9O8S |
| CAS | 125989-15-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Munro FE, Fleetwood-Walker SM, Parker RM, Mitchell R. The effects of neurokinin receptor antagonists on mustard oil-evoked activation of rat dorsal horn neurons. Neuropeptides. 1993 Nov;25(5):299-305. PubMed PMID: 8115032. 2. Fleetwood-Walker SM, Parker RM, Munro FE, Young MR, Hope PJ, Mitchell R. Evidence for a role of tachykinin NK2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae III-V) neurons. Eur J Pharmacol. 1993 Sep 28;242(2):173-81. PubMed PMID: 8253113. 3. Fan TP, Hu DE, Guard S, Gresham GA, Watling KJ. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol. 1993 Sep;110(1):43-9. PubMed PMID: 7693287; PubMed Central PMCID: PMC2176009. 4. Hall JM, Flowers JM, Morton IK. A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder. Br J Pharmacol. 1992 Nov;107(3):777-84. PubMed PMID: 1282072; PubMed Central PMCID: PMC1907736. |