| Description | L 659,877 is an antagonist of the Tachykinin and neurokinin-2 receptor. |
| Synonyms | L 659877, L-659,877, L-659877, L659,877, L659877 |
| molecular weight | 762.92 |
| Molecular formula | C38H50N8O7S |
| CAS | 125989-12-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Chen X, Yu L, Steill JD, Oomens J, Polfer NC. Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8). J Am Chem Soc. 2009 Dec 30;131(51):18272-82. doi: 10.1021/ja9030837. PubMed PMID: 19947633. 2. Li H, Bao Y, Zhao Z. Expression of tachykinin receptors inXenopus oocytes injected with poly (A)(+) RNA from cat dorsal root ganglion. Sci China C Life Sci. 1998 Apr;41(2):139-45. doi: 10.1007/BF02882718. PubMed PMID: 18726197. 3. Minowa S, Tsuchiya S, Someya A, Horie S, Murayama T. Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain. Eur J Pharmacol. 2004 Feb 23;486(3):317-24. PubMed PMID: 14985054. 4. Gaspar MN, Ribeiro CA, Cunha-Vaz JG, Macedo TR. Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits. Pharmacology. 2004 Mar;70(3):152-9. PubMed PMID: 14752235. |