| Description | L 645151 is an inhibitor of lipophilic CA. |
| Synonyms | L645151, L-645151 |
| molecular weight | 314.38 |
| Molecular formula | C12H14N2O4S2 |
| CAS | 86394-94-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wetzel P, Kleinke T, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase slows the Ca(2+) transient in rat skeletal muscle fibers. Am J Physiol Cell Physiol. 2002 Oct;283(4):C1242-53. PubMed PMID: 12225987. 2. Wetzel P, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres. Pflugers Arch. 2002 Mar;443(5-6):762-70. Epub 2002 Jan 22. PubMed PMID: 11889574. 3. Woltersdorf OW Jr, Schwam H, Bicking JB, Brown SL, deSolms SJ, Fishman DR, Graham SL, Gautheron PD, Hoffman JM, Larson RD, et al. Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide. J Med Chem. 1989 Nov;32(11):2486-92. PubMed PMID: 2810337. 4. Bar-Ilan A, Pessah NI, Maren TH. Ocular penetration and hypotensive activity of the topically applied carbonic anhydrase inhibitor L-645,151. J Ocul Pharmacol. 1986 Spring;2(2):109-20. PubMed PMID: 3503100. |