| Description | KYN-101 is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO. |
| molecular weight | 386.42 |
| Molecular formula | C22H19FN6 |
| CAS | 2247950-73-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |