| Description | KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid. |
| In vitro | KSC-34 在体外显示出对 PDIA1 还原酶活性的时间依赖性抑制，其 kinact/KI 为 9.66 × 103 M-1 s-1，并且对 PDI 家族的其他成员以及其他细胞中含有半胱氨酸的蛋白质具有选择性[1]。 |
| Target activity | PDIA1 (a domain):3.5 μM, PDIA1 (a' domain):104.5 μM |
| molecular weight | 429.95 |
| Molecular formula | C21H28ClN7O |
| CAS | 2226201-97-2 |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (186.07 mM), Sonication is recommended. |
| References | 1. Cole KS,et al. Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor. Biochemistry. 2018 Apr 3;57(13):2035-2043. |