| Description | KRM-II-81 is a γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand. KRM-II-81 exhibits improved anxiolytic-like effects in a mouse marble burying assay and a rat Vogel conflict test. |
| Synonyms | KRM-II81, KRM-II 81 |
| molecular weight | 351.36 |
| Molecular formula | C21H13N5O |
| CAS | 2014348-91-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy Michael M. Poe, Kashi Reddy Methuku, Guanguan Li, Ashwini R. Verma, Kelly A. Teske, Douglas C. Stafford, Leggy A. Arnold, Jeffrey W. Cramer, Timothy M. Jones, Rok Cerne, Michael J. Krambis, Jeffrey M. Witkin, Enrique Jambrina, Sabah Rehman, Margot Ernst, James M. Cook, and Jeffrey M. Schkeryantz Publication Date (Web): November 11, 2016 (Brief Article) doi: 10.1021/acs.jmedchem.6b01332 |