| Description | KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17, with an IC50 value of 11.1 nM/L in cell-free assays. The compound can also cleave a variety of molecules, including GPIbα, GPV and TNF-α. |
| Synonyms | TNF‐α‐converting enzyme |
| molecular weight | 480.56 |
| Molecular formula | C21H24N2O7S2 |
| CAS | 1365803-52-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Hirata S, et al. Stem Cells Transl Med. 2017 Mar;6(3):720-730. |