| Description | KNI-1657 is a potent and selective HIV-1 protease inhibitor (Anti-HIV-1 pNL4-3, EC50: 3 nM). KNI-1657 is a highly potent HIV-1 Protease Inhibitor against Lopinavir. |
| molecular weight | 756.92 |
| Molecular formula | C41H48N4O8S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hidaka K, Kimura T, Sankaranarayanan R, Wang J, McDaniel KF, Kempf DJ, Kameoka M, Adachi M, Kuroki R, Nguyen JT, Hayashi Y, Kiso Y. Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine. J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.7b01709. [Epub ahead of print] PubMed PMID: 29852069. |