| Description | KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. |
| In vitro | KL201在Bmal1-dLuc报告细胞中引起剂量依赖性的昼夜节律周期延长，并且在带有另一个昼夜节律报告基因Per2-dLuc的细胞中也有相同作用。对Per2-dLuc报告基因的抑制作用明显大于Bmal1-dLuc，同时不影响细胞活力[1]。KL201与CRY1结合，在与FBXL3（一种泛素连接酶复合体的亚基）重叠的部位，且KL201的效果被FBXL3的减弱所削弱[1]。在小鼠肺原代培养中，KL201延长了昼夜节律周期，并显著抑制了Per2::Luc敲入报告基因的强度[1]。 |
| molecular weight | 388.28 |
| Molecular formula | C17H14BrN3OS |
| CAS | 302939-48-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 250 mg/mL (643.87 mM), Sonication is recommended. |