| Description | KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP/PKA/CREB pathway. |
| In vitro | KL044 (0-3.7 μM;8 h) 在基于细胞的降解试验中有效稳定了 CRY1-LUC 融合蛋白，而不影响 LUC 稳定性[1] |
| Synonyms | KL 044, KL-044 |
| molecular weight | 359.81 |
| Molecular formula | C21H14ClN3O |
| CAS | 1801856-93-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Jae Wook Lee, et al. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97. |