| Description | KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria. |
| In vitro | 患者源性异种移植瘤模型中，缺乏琥珀酸脱氢酶A（SDHA）的癌症对KL-11743特别敏感，直接证明了TCA循环突变肿瘤在体内对GLUT抑制剂易感[1]。 |
| Target activity | GLUT3:90 nM (IC50), GLUT4:68 nM (IC50), GLUT2:137 nM (IC50), GLUT1:115 nM (IC50) |
| molecular weight | 522.6 |
| Molecular formula | C30H30N6O3 |
| CAS | 1369452-53-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (47.84 mM) |
| References | 1. Olszewski K, et al. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2021 Oct 22:S2451-9456(21)00441-4. |