| Description | KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, demonstrating an IC50 of 0.26 μM. It exerts its antidepressant effects in mice by inhibiting HDAC6 within the brain. Therefore, KH-259 holds promise as a valuable tool for neurodegenerative diseases research [1]. |
| In vitro | KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes [1]. |
| In vivo | KH-259 (compound 1) (10 mg/kg, IP, once) in mice significantly increases acetylated α-tubulin levels without increasing acetylated histone H3K9 levels in the brain, indicating that KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain [1]. |
| molecular weight | 339.43 |
| Molecular formula | C20H25N3O2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |