| Description | KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein. |
| In vitro | KF 38789抑制了U937细胞与固定化的P-selectin免疫球蛋白G嵌合蛋白(P-selectin-Ig)的结合，IC50值为1.97 microM。KF 38789对E-selectin-Ig和L-selectin-Ig的细胞黏附作用即使在100 microM的浓度下也无影响。此外，KF 38789抑制了P-selectin诱导的人类多形核白细胞产生超氧化物。通过静脉注射KF 38789显著抑制了在小鼠腹腔内TG诱导的白细胞积聚（p<0.01）[1]。 |
| In vivo | KF 38789 在面部注射卡拉胶的小鼠中显著降低了机械性痛觉过敏[2]。 |
| Target activity | P-selectin-Ig:1.97 microM |
| Synonyms | KF 38789 |
| molecular weight | 375.44 |
| Molecular formula | C19H21NO5S |
| CAS | 257292-29-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 11.25 mg/mL (29.96 mM) |
| References | 1. S Ohta, et al. Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38789. Inflamm Res. 2001 Nov;50(11):544-51. 2. Kay-Wee Poh, et al. Global gene expression analysis in the mouse brainstem after hyperalgesia induced by facial carrageenan injection--evidence for a form of neurovascular coupling? Pain. 2009 Mar;142(1-2):133-41. 3. Peter J Gillies, et al. Demonstration of P-selectin expression and potential function in human corneal epithelial cells. Exp Eye Res. 2018 Nov;176:196-206. |