| Description | K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C.. |
| In vitro | K-Ras G12C-IN-4在4小时内给予抑制MIA PaCa-2细胞的MAPK信号转导路径（p-ERK），IC50值为0.219 μM[1]。在对MIA PaCa-2细胞进行72小时的CellTiter-Glo活性测试中，K-Ras G12C-IN-4可抑制其细胞活性，IC50为0.067 μM[1]。 |
| Target activity | PERK:0.219 μM |
| molecular weight | 561.07 |
| Molecular formula | C31H33ClN4O4 |
| CAS | 2376328-55-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (89.115 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308. |