| Description | JNJ-DGAT2-A, a specific inhibitor of DGAT2(IC50 = 0.14 μM), can be used in studies about the synthesis of triglycerides. |
| In vitro | JNJ-DGAT2-A (5 μM) almost completely inhibits the enzymatic activity of recombinant DGAT2 and DGAT2 activity in HepG2 cell lysates. In HepG2 cells, JNJ-DGAT2-A (0.3125-20 µM) inhibits the generation of TG (50:2), TG (52:2), and TG (54:3) in a dose-dependent manner with IC50 values of 0.66, 0.85, and 0.99 μM, respectively[1]. |
| Target activity | DGAT-2 (Sf9 insect cell membranes ):0.14 μM |
| Synonyms | JNJDGAT2A |
| molecular weight | 523.38 |
| Molecular formula | C24H16BrFN4O2S |
| CAS | 1962931-71-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.0 mg/mL (5.7 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Qi J, Lang W, Geisler JG, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. Journal of Lipid Research. 2012;53(6):1106-1116. |