| Description | JNJ-7925476 HCl is a triple monoamine uptake inhibitor. JNJ-7925476 Salt blocks the dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter (SERT) in the central nervous system. The ED(50) values for JNJ-7925476 occupancy of the DAT, NET and SERT in rat brain were 2.4, 0.09, 0.18 and mg/kg, respectively. |
| Synonyms | JNJ-7925476, JNJ7925476, JNJ 7925476 |
| molecular weight | 309.83 |
| Molecular formula | C20H20ClN |
| CAS | 109085-56-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Aluisio L, Lord B, Barbier AJ, Fraser IC, Wilson SJ, Boggs J, Dvorak LK, Letavic MA, Maryanoff BE, Carruthers NI, Bonaventure P, Lovenberg TW. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor. Eur J Pharmacol. 2008 Jun 10;587(1-3):141-6. doi: 10.1016/j.ejphar.2008.04.008. Epub 2008 Apr 10. PubMed PMID: 18499098. |