| Description | JNJ-55511118 is a selective negative modulator of AMPA receptors containing TARP-γ8 (Ki: 26 nM). It had excellent pharmacokinetic properties. JNJ-55511118 exhibited a dose-dependent inhibition of neurotransmission within the hippocampus and a strong anticonvulsant effect. |
| Synonyms | JNJ 55511118 |
| molecular weight | 328.67 |
| Molecular formula | C14H8ClF3N2O2 |
| CAS | 2036081-86-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Maher MP, Wu N, Ravula S, Ameriks MK, Savall BM, Liu C, Lord B, Wyatt RM, Matta JA, Dugovic C, Yun S, Ver Donck L, Steckler T, Wickenden AD, Carruthers NI, Lovenberg TW. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016 May;357(2):394-414. doi: 10.1124/jpet.115.231712. Epub 2016 Mar 17. PubMed PMID: 26989142. |