| Description | JNJ-28610244 is a specific agonist of the H4 receptor. It acts by blocking Mac-1-dependent activation of p38 MAPK. |
| Synonyms | JNJ 28610244 |
| molecular weight | 271.36 |
| Molecular formula | C16H21N3O |
| CAS | 1251462-28-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Dib K, Perecko T, Jenei V, McFarlane C, Comer D, Brown V, Katebe M, Scheithauer T, Thurmond RL, Chazot PL, Ennis M. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. J Leukoc Biol. 2014 Sep;96(3):411-8. doi: 10.1189/jlb.2AB0813-432RR. Epub 2014 May 5. PubMed PMID: 24799603; PubMed Central PMCID: PMC5395935. 2. Desai P, Thurmond RL. Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. Eur J Immunol. 2011 Jun;41(6):1764-73. doi: 10.1002/eji.201040932. Epub 2011 May 25. PubMed PMID: 21469095. |