| Description | JMS-17-2 hydrochloride, a highly potent and selective CX3CR1 antagonist with an IC 50 value of 0.32 nM, effectively impedes the metastatic seeding and colonization process of breast cancer cells. |
| In vivo | JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1]. Animal Model: SCID mice (~25g) with MDA-231 xenograft[1]Dosage: 10 mg/kg Administration: Aministered i.p.; twice a day for three weeks Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs. |
| Target activity | CX3CR1:0.32 nM (IC50) |
| molecular weight | 456.41 |
| Molecular formula | C25H27Cl2N3O |
| CAS | 2341841-07-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. |