| Description | JH-XVI-178 is a highly potent and selective CDK8/19 inhibitor with favorable pharmacokinetic attributes, including low clearance and moderate oral bioavailability. |
| Target activity | CDK19:2 nM (IC50), CDK8:1 nM (IC50) |
| molecular weight | 435.92 |
| Molecular formula | C22H22ClN7O |
| CAS | 2648453-53-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12(11):1689-1693. |