| Description | JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. It exhibits remarkable antibiotic activity, reflected by a minimal inhibitory concentration (MIC) value of 0.66 μg/mL. |
| In vitro | JH-LPH-33 potently inhibits bacterial growth at 1.6 μg/mL and displayes a MIC value of >64 μg/mL against E. coli. JH-LPH-33 displays IC50 values of 0.026 μM against K. pneumoniae LpxH and 0.046 μM against E. coli LpxH, respectively. |
| molecular weight | N/A |
| CAS | 2414590-04-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116. |